Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Chemical reporters for bacterial glycans: development and applications

N Banahene, HW Kavunja, BM Swarts - Chemical reviews, 2021 - ACS Publications
Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical
physiological functions. Pathogenic bacteria have glycans that are essential for growth and …

The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

CJ Cambier, KK Takaki, RP Larson, RE Hernandez… - Nature, 2014 - nature.com
The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis,
depends on its ability to invade the host, replicate, and transmit infection. At its initial …

Cell-mediated immune responses in tuberculosis

AM Cooper - Annual review of immunology, 2009 - annualreviews.org
Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …

The mycobacterial cell envelope—lipids

M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

Unexpected Role for IL-17 in Protective Immunity against Hypervirulent Mycobacterium tuberculosis HN878 Infection

R Gopal, L Monin, S Slight, U Uche, E Blanchard… - PLoS …, 2014 - journals.plos.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one third
of the world's population. Among these infections, clinical isolates belonging to the W …

Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages

D Portevin, S Gagneux, I Comas, D Young - PLoS pathogens, 2011 - journals.plos.org
The aim of the present study was to determine whether there is a correlation between
phylogenetic relationship and inflammatory response amongst a panel of clinical isolates …