Autism is a complex, behaviorally defined, static disorder of the immature brain that is of
great concern to the practicing pediatrician because of an astonishing 556% reported …

Since autism was first recognized as a disorder in 1943, speculation about its aetiology has
ranged from biological to psychological and back again. After twin studies during the 1970s …

Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …

Context Autism is a neurodevelopmental disorder that is characterized by repetitive and/or
obsessive interests and behavior and by deficits in sociability and communication. Although …

All of the serotonin-producing neurons of the mammalian brain are located in 10 nuclei in
the mid-and hindbrain regions. The cells of the rostal nuclei project to almost every area of …

Review of neurochemical investigations in autistic disorder revealed that a wide array of
transmitter systems have been studied, including serotonin, dopamine, norepinephrine …

Reviewers in the 1960s and early 1970s were skeptical about any substantial role for
genetic factors in the etiology of autism. A realization that the 2% rate of autism in siblings …

An increasing number of publications are replicating a previously reported disease-marker
association but with the risk allele reversed from the previous report. Do such" flip-flop" …

Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology
exhibiting deficits in (1) development of language and (2) social relationships and (3) …

The autism spectrum disorders (ASD) comprise a complex group of behaviorally related
disorders that are primarily genetic in origin. Involvement of epigenetic regulatory …