Rabies is one of the most deadly infectious diseases, with a case-fatality rate approaching
100%. The disease is established on all continents apart from Antarctica; most cases are …

Rabies is a zoonotic, fatal and progressive neurological infection caused by rabies virus of
the genus Lyssavirus and family Rhabdoviridae. It affects all warm-blooded animals and the …

Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …

The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …

Rabies is an almost invariably fatal disease that can present as classic furious rabies or
paralytic rabies. Recovery has been reported in only a few patients, most of whom were …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …

The retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated antigen
5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such …

The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute
respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other …