Organoboron reagents represent a unique class of compounds because of their utility in
modern synthetic organic chemistry, often affording unprecedented reactivity. The …

Chiral organoboronates have played a critical role in organic chemistry and in the
development of materials science and pharmaceuticals. Much effort has been devoted to …

Recent research in medicinal chemistry has suggested that there is a correlation between
an increase in the fraction of sp 3 carbons—those bonded to four other atoms—in drug …

Developing synthetically useful enzymatic reactions that are not known in biochemistry and
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …

Organoborons have emerged as versatile building blocks in organic synthesis to achieve
molecular diversity and as carboxylic acid bioisosteres with broad applicability in drug …

Abstract Bicyclic hydrocarbons, and bicyclo [1.1. 1] pentanes (BCPs) in particular, are
playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and …

Although known for over 90 years, only in the past two decades has the chemistry of diboron
(4) compounds been extensively explored. Many interesting structural features and reaction …

The conversion of widely available carboxylic acids into versatile boronic esters would be
highly enabling for synthesis. We found that this transformation can be effected by …

Organoboron reagents are one of the most widely studied and applied classes of reagent
throughout organic synthesis and catalysis. Not only are these reagents integral to many of …

Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (SN1 and
SN2) have limited scope and are not generally amenable to enantioselective variants that …