GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

A Lippa, MM Poe, JL Smith, X Jin, X Ping… - Pharmacology & …, 2022 - Elsevier
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction

R Pal, K Singh, SA Khan, P Chawla, B Kumar… - European Journal of …, 2021 - Elsevier
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …

[HTML][HTML] Citrus limon L.(lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing …

MM Rahman, F Islam, A Parvez, MAK Azad… - Journal of Integrative …, 2022 - imrpress.com
Citrus limon L. is an ingenious alternative medication and has a broad scope in managing
several health conditions as part of natural remedies. Recently, medicinal plants have …

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

F Islam, S Mitra, MH Nafady… - Evidence‐Based …, 2022 - Wiley Online Library
The present study examines the neuropharmacological and antidiabetic properties of
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …

A study on synthesis of benzodiazepine scaffolds using biologically active chalcones as precursors

AS Bhathiwal, A Bendi, A Tiwari - Journal of Molecular Structure, 2022 - Elsevier
Nowadays, heterocyclic compounds have attained a prominent place among the numerous
classes of aromatic organic compounds in medicinal chemistry due to their important …

Recent Advances in Transition‐Metal‐Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines

Á Velasco‐Rubio, JA Varela… - Advanced Synthesis & …, 2020 - Wiley Online Library
Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles,
compose an important family of natural products and pharmaceuticals. Although certainly …

[HTML][HTML] Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats

R Sahu, S Mehan, S Kumar, A Prajapati, A Alshammari… - Toxicology reports, 2022 - Elsevier
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …

ESIPT-active cinnamoyl pyrones are bright solid-state emitters: Revisited theoretical approach and experimental study

E Bremond, M Boggio-Pasqua, N Leygue, M Fodili… - Dyes and …, 2023 - Elsevier
Excited-state intramolecular proton transfer (ESIPT) is a photophysical process that may
lead to superior emission properties. For a long time, cinnamoyl pyrone (CP) derivatives …

Anticonvulsant Classes and Possible Mechanism of Actions

WH Abd-Allah, MA El-Mohsen Anwar… - ACS Chemical …, 2023 - ACS Publications
Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …

Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents

H Singh, R Kumar, A Mazumder, Salahuddin… - Medicinal Chemistry …, 2022 - Springer
In humans, epilepsy becomes a serious health problem due to scarcity of effective
medications against it. Most of the available anti-epileptic drugs have severe adverse effects …