GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
[HTML][HTML] Citrus limon L.(lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing …
Citrus limon L. is an ingenious alternative medication and has a broad scope in managing
several health conditions as part of natural remedies. Recently, medicinal plants have …
several health conditions as part of natural remedies. Recently, medicinal plants have …
Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis
F Islam, S Mitra, MH Nafady… - Evidence‐Based …, 2022 - Wiley Online Library
The present study examines the neuropharmacological and antidiabetic properties of
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …
A study on synthesis of benzodiazepine scaffolds using biologically active chalcones as precursors
AS Bhathiwal, A Bendi, A Tiwari - Journal of Molecular Structure, 2022 - Elsevier
Nowadays, heterocyclic compounds have attained a prominent place among the numerous
classes of aromatic organic compounds in medicinal chemistry due to their important …
classes of aromatic organic compounds in medicinal chemistry due to their important …
Recent Advances in Transition‐Metal‐Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines
Á Velasco‐Rubio, JA Varela… - Advanced Synthesis & …, 2020 - Wiley Online Library
Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles,
compose an important family of natural products and pharmaceuticals. Although certainly …
compose an important family of natural products and pharmaceuticals. Although certainly …
[HTML][HTML] Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …
ESIPT-active cinnamoyl pyrones are bright solid-state emitters: Revisited theoretical approach and experimental study
E Bremond, M Boggio-Pasqua, N Leygue, M Fodili… - Dyes and …, 2023 - Elsevier
Excited-state intramolecular proton transfer (ESIPT) is a photophysical process that may
lead to superior emission properties. For a long time, cinnamoyl pyrone (CP) derivatives …
lead to superior emission properties. For a long time, cinnamoyl pyrone (CP) derivatives …
Anticonvulsant Classes and Possible Mechanism of Actions
WH Abd-Allah, MA El-Mohsen Anwar… - ACS Chemical …, 2023 - ACS Publications
Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …
Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents
In humans, epilepsy becomes a serious health problem due to scarcity of effective
medications against it. Most of the available anti-epileptic drugs have severe adverse effects …
medications against it. Most of the available anti-epileptic drugs have severe adverse effects …