Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …

Reactive oxygen species (ROS) have been identified as signaling molecules in various
pathways regulating both cell survival and cell death. Autophagy, a self-digestion process …

Elevated levels of reactive nitrogen species, alteration in redox balance and deregulated
redox signaling are common hallmarks of cancer progression and chemoresistance …

Cancer formation is a highly regulated and complex process, largely dependent on its
microenvironment. This complexity highlights the need for developing novel target-based …

The incidence of cardiovascular disease (CVD) is lower in premenopausal women but
increases with age and menopause compared with similarly aged men. Based on the …

Microtubules are polar cytoskeletal filaments assembled from head-to-tail and comprised of
lateral associations of α/β-tubulin heterodimers that play key role in various cellular …