Probing the mechanism of nick searching by LIG1 at the single-molecule level
S Chatterjee, L Chaubet, A van den Berg… - Nucleic Acids …, 2024 - academic.oup.com
Abstract DNA ligase 1 (LIG1) joins Okazaki fragments during the nuclear replication and
completes DNA repair pathways by joining 3′-OH and 5′-PO4 ends of nick at the final …
completes DNA repair pathways by joining 3′-OH and 5′-PO4 ends of nick at the final …
[HTML][HTML] Structures of LIG1 uncover the mechanism of sugar discrimination against 5′-RNA-DNA junctions during ribonucleotide excision repair
Ribonucleotides in DNA cause several types of genome instability and can be removed by
ribonucleotide excision repair (RER) that is finalized by DNA ligase 1 (LIG1). However, the …
ribonucleotide excision repair (RER) that is finalized by DNA ligase 1 (LIG1). However, the …