Protein kinase C and cancer: what we know and what we do not
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
Protein kinase C (PKC) isozymes and cancer
JH Kang - New Journal of Science, 2014 - Wiley Online Library
Protein kinase C (PKC) is a family of phospholipid‐dependent serine/threonine kinases,
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
which can be further classified into three PKC isozymes subfamilies: conventional or classic …
Anthocyanins from Hibiscus sabdariffa calyx attenuate in vitro and in vivo melanoma cancer metastasis
CC Su, CJ Wang, KH Huang, YJ Lee, WM Chan… - Journal of Functional …, 2018 - Elsevier
Melanoma cell metastasis is the main cause of patient death. To develop more effective
strategies for the prevention or treatment of melanoma, we investigated the inhibitory effects …
strategies for the prevention or treatment of melanoma, we investigated the inhibitory effects …
The complexities of PKCα signaling in cancer
AR Black, JD Black - Advances in biological regulation, 2021 - Elsevier
Protein kinase C α (PKCα) is a ubiquitously expressed member of the PKC family of
serine/threonine kinases with diverse functions in normal and neoplastic cells. Early studies …
serine/threonine kinases with diverse functions in normal and neoplastic cells. Early studies …
Analysis of lncRNAs expression in UVB-induced stress responses of melanocytes
Q Zeng, Q Wang, X Chen, K Xia, J Tang, X Zhou… - Journal of …, 2016 - Elsevier
Abstract Background Long non-coding RNAs (lncRNAs) have close relationships with
oxidative stress, nutritional deficiency, DNA damage and other types of cellular stress …
oxidative stress, nutritional deficiency, DNA damage and other types of cellular stress …
Specifying protein kinase C functions in melanoma
MF Denning - Pigment cell & melanoma research, 2012 - Wiley Online Library
The protein kinase C (PKC) family of serine/threonine protein kinases is a heterogeneous
group of enzymes receiving and integrating signals involved in both normal melanocyte …
group of enzymes receiving and integrating signals involved in both normal melanocyte …
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β
N Yoon, MS Park, T Shigemoto, G Peltier… - Cell death & disease, 2016 - nature.com
Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are
activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) …
activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) …
Protein kinase C alpha is a central node for tumorigenic transcriptional networks in human prostate cancer
Aberrant expression of protein kinase C (PKC) isozymes is a hallmark of cancer. The
different members of the PKC family control cellular events associated with cancer …
different members of the PKC family control cellular events associated with cancer …
Protein kinase C-α is upregulated by IMP1 in melanoma and is linked to poor survival
L Mahapatra, N Andruska, C Mao, SB Gruber… - Melanoma …, 2019 - journals.lww.com
The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding
protein 1 (IGF2BP1), promotes the overexpression of several oncogenic proteins by binding …
protein 1 (IGF2BP1), promotes the overexpression of several oncogenic proteins by binding …
Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo
SD Smith, M Enge, W Bao, M Thullberg… - Journal of Biological …, 2012 - ASBMB
Protein kinase C α (PKCα) is overexpressed in numerous types of cancer. Importantly, PKCα
has been linked to metastasis of malignant melanoma in patients. However, it has been …
has been linked to metastasis of malignant melanoma in patients. However, it has been …