Chromosome segregation errors in human oocytes lead to aneuploid embryos that cause
infertility and birth defects. Here we provide an overview of the chromosome-segregation …

Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells, the
oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to …

Mitochondria are highly dynamic organelles and their distribution, structure and activity
affect a wide range of cellular functions. Mitochondrial membrane potential (∆ Ψm) is an …

Mammalian oocytes spend most of their life in a unique state of cell cycle arrest at meiotic
prophase I, during which time they are exposed to countless DNA-damaging events. Recent …

Background Breast cancer is one of the most common endocrine cancers among females
worldwide. Distant metastasis of breast cancer is causing an increasing number of breast …

Meiosis poses unique challenges because two rounds of chromosome segregation must be
executed without intervening DNA replication. Mammalian cells express numerous …

The purpose of meiosis is to generate developmentally competent, haploid gametes with the
correct number of chromosomes. For reasons not completely understood, female meiosis is …

Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of
our understanding of their functions has been obtained from studies in single-cell organisms …

Ovary development is an important determinant of the procreative capacity of female
animals. Here, we performed genome-wide sequencing of long non-coding RNAs …

The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation
of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that …