Stress is a common occurrence in everyday life and repeated or traumatic stress can be a
precipitating factor for illnesses of the central nervous system, as well as peripheral organ …

Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal
(HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By virtue of nearly …

Increasing amounts of data suggest that inflammatory responses have an important role in
the pathophysiology of depression. Depressed patients have been found to have higher …

Little is known about the mechanisms converting psychosocial stress into cellular
dysfunction. Various genes, up-regulated in atherosclerosis but also by psychosocial stress …

Recently, the inflammatory and neurodegenerative (I&ND) hypothesis of depression was
formulated (Maes et al., 2009), ie the neurodegeneration and reduced neurogenesis that …

This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …

Glucocorticoids (GCs) are hormones released during the stress response that are well
known for their immunosuppressive and anti-inflammatory properties; however, recent …

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune
response and have been used since decades to treat various inflammatory and autoimmune …

Vitamin D insufficiency is common in the United States; the elderly and African‐Americans
are at particularly high risk of deficiency. This review, written for a broad scientific …