Systems biology, systems medicine, systems pharmacology: the what and the why

A Stéphanou, E Fanchon, PF Innominato, A Ballesta - Acta biotheoretica, 2018 - Springer
Abstract Systems biology is today such a widespread discipline that it becomes difficult to
propose a clear definition of what it really is. For some, it remains restricted to the genomic …

[HTML][HTML] Multiscale computing in the exascale era

S Alowayyed, D Groen, PV Coveney… - Journal of Computational …, 2017 - Elsevier
We expect that multiscale simulations will be one of the main high performance computing
workloads in the exascale era. We propose multiscale computing patterns as a generic …

Assessing the effect of incretin hormones and other insulin secretagogues on pancreatic beta-cell function: review on mathematical modelling approaches

G Pacini, B Ahrén, C Göbl, A Tura - Biomedicines, 2022 - mdpi.com
Mathematical modelling in glucose metabolism has proven very useful for different reasons.
Several models have allowed deeper understanding of the relevant physiological and …

[HTML][HTML] Non-intrusive and semi-intrusive uncertainty quantification of a multiscale in-stent restenosis model

D Ye, A Nikishova, L Veen, P Zun… - Reliability Engineering & …, 2021 - Elsevier
Abstract The In-Stent Restenosis 2D model is a full y coupled multiscale simulation of post-
stenting tissue growth, in which the most costly submodel is the blood flow simulation. This …

[图书][B] Computational Immunology: Applications

S Ghosh - 2020 - taylorfrancis.com
Computational Immunology: Applications focuses on different mathematical models,
statistical tools, techniques, and computational modelling that helps in understanding …

[图书][B] Patterns for multiscale computing

SA Alowayyed - 2018 - dare.uva.nl
Multiscale computing involves the modelling, characterisation and simulation of complex
phenomena on several interacting space and/or time scales. We simulate multiscale models …

Network-guided key gene discovery for a given cellular process

FQ He, M Ollert - 2016 - Springer
Identification of key genes for a given physiological or pathological process is an essential
but still very challenging task for the entire biomedical research community. Statistics-based …

[PDF][PDF] Ontology Creation and Management Tools: the Case of Anatomical Connectivity

N Kokash, B de Bono, T Gillespie - nkokash.com
We are developing infrastructure to support researchers in mapping data related to the
peripheral nervous system and other physiological systems, with an emphasis on their …