Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To
support this malignant phenotype, cells acquire molecular alterations that abrogate or …

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment
of centrosomes, a state referred to as centrosome amplification (CA). CA can drive …

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer
cells often display centrosome amplification. To maintain survival, cancer cells achieve …

Breast cancer is the most common cancer in women with increasing insidance. Breast
cancer occurs as a result of some molecular changes, such as aberrant or dysregulated …

Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …

Simple Summary Precise chromosome segregation during mitosis is a vital event
orchestrated by formation of bipolar spindle poles. Supernumerary centrosomes, caused by …

Much research has focused on finding novel prognostic biomarkers for triple negative breast
cancer (TNBC), whereas only scattered information about the relation between …

The synaptonemal complex (SC) is a supramolecular protein scaffold that mediates
chromosome synapsis and facilitates crossing over during meiosis. In mammals, SC …

Simple Summary Quadruple negative breast cancer (QNBC), a subgroup of triple negative
BC, has emerged as a highly aggressive BC subtype that disproportionately afflicts and …

Although subcellular positioning of endosomes significantly impacts on their functions, the
molecular mechanisms governing the different steady‐state distribution of early endosomes …