[HTML][HTML] Iron metabolism and ferroptosis: A pathway for understanding preeclampsia

KE Gumilar, B Priangga, CH Lu, EG Dachlan… - Biomedicine & …, 2023 - Elsevier
Preeclampsia (PE) is a serious medical condition that poses a significant health risk to
women and children worldwide, particularly in the middle-and low-income countries. It is a …

Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1

P Doria-Borrell, V Pérez-García - Communications Biology, 2024 - nature.com
The placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and
hormonal signaling between the mother and the developing fetus. Understanding its …

Procyanidins alleviated cerebral ischemia/reperfusion injury by inhibiting ferroptosis via the Nrf2/HO-1 signaling pathway

L Chen, J Huang, ZM Yao, XR Sun, XH Tong, M Hu… - Molecules, 2023 - mdpi.com
Procyanidins (PCs), which are organic antioxidants, suppress oxidative stress, exhibit anti−
apoptotic properties, and chelate metal ions. The potential defense mechanism of PCs …

Development and validation of a novel ferroptosis-related LncRNA signature for predicting prognosis and the immune landscape features in uveal melanoma

X Ma, S Yu, B Zhao, W Bai, Y Cui, J Ni, Q Lyu… - Frontiers in …, 2022 - frontiersin.org
Background Ferroptosis is a newly iron-dependent mode of programmed cell death that is
involved in a variety of malignancies. But no research has shown a link between ferroptosis …

[HTML][HTML] Impact of ferroptosis on preeclampsia: A review

Y Shan, C Guan, J Wang, W Qi, A Chen… - Biomedicine & …, 2023 - Elsevier
Preeclampsia (PE) is usually associated with the accumulation of reactive oxygen species
(ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid …

Role of ferroptosis in pregnancy related diseases and its therapeutic potential

J Xu, F Zhou, X Wang, C Mo - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming
lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that …

Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway

J Lu, J Wang, K Han, N Li - Inflammation, 2024 - Springer
This study mainly explored the role of nicorandil in regulating ferroptosis and alleviating
septic cardiomyopathy through toll-like receptor (TLR) 4/solute carrier family 7 member 11 …

Placental ion channels: potential target of chemical exposure

Y Zhao, M Pasanen, J Rysä - Biology of Reproduction, 2023 - academic.oup.com
The placenta is an important organ for the exchange of substances between the fetus and
the mother, hormone secretion, and fetoplacental immunological defense. Placenta has an …

[HTML][HTML] The crosstalk between cell death and pregnancy related diseases: A narrative review

X Xie, J Liu, J Gao, C Shang, Y Jiang, L Chen… - Biomedicine & …, 2024 - Elsevier
Programmed cell death is intricately linked to various physiological phenomena such as
growth, development, and metabolism, as well as the proper function of the pancreatic β cell …

Reversal of H2O2-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis

M Cao, W Jin, Y Li, M Wang, F Wan, Y Ren… - Functional & Integrative …, 2023 - Springer
Preeclampsia is a serious threat to the health of pregnant women. Injury of trophoblasts
could contribute to the progression of preeclampsia, and H2O2 was able to induce …