Genetic risk factors for type 1 diabetes
F Pociot, Å Lernmark - The Lancet, 2016 - thelancet.com
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …
Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity
J Wu, LJ Yan - Diabetes, metabolic syndrome and obesity: targets …, 2015 - Taylor & Francis
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
The immunobiology of interleukin-27
H Yoshida, CA Hunter - Annual review of immunology, 2015 - annualreviews.org
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …
response. Although it was initially linked with the development of Th1 responses, it is now …
IL-27-induced modulation of autoimmunity and its therapeutic potential
Abstract Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
Clinically relevant circulating protein biomarkers for type 1 diabetes: evidence from a two-sample Mendelian randomization study
N Yazdanpanah, M Yazdanpanah, Y Wang… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To identify circulating proteins influencing type 1 diabetes susceptibility using
Mendelian randomization (MR). RESEARCH DESIGN AND METHODS We used a large …
Mendelian randomization (MR). RESEARCH DESIGN AND METHODS We used a large …
Increased blood levels of growth factors, proinflammatory cytokines, and Th17 cytokines in patients with newly diagnosed type 1 diabetes
K Alnek, K Kisand, K Heilman, A Peet, K Varik, R Uibo - PloS one, 2015 - journals.plos.org
The production of several cytokines could be dysregulated in type 1 diabetes (T1D). In
particular, the activation of T helper (Th) type 1 (Th1) cells has been proposed to underlie …
particular, the activation of T helper (Th) type 1 (Th1) cells has been proposed to underlie …
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation
AE Ciecko, B Foda, JY Barr, S Ramanathan… - Cell reports, 2019 - cell.com
Human genetic studies implicate interleukin-27 (IL-27) in the pathogenesis of type 1
diabetes (T1D), but the underlying mechanisms remain largely unexplored. To further define …
diabetes (T1D), but the underlying mechanisms remain largely unexplored. To further define …
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma
LV Márquez-Quiroga, J Arellanes-Robledo… - Biochemical …, 2022 - Elsevier
Hepatocellular carcinoma (HCC), the most common primary liver cancer, arises after a long
period of exposure to etiological factors. Nonalcoholic steatohepatitis (NASH) is ranked as …
period of exposure to etiological factors. Nonalcoholic steatohepatitis (NASH) is ranked as …
Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy
M Zychowska, E Rojewska, G Kreiner, I Nalepa… - Journal of …, 2013 - Elsevier
A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …
with an increase in plasma glucose levels and a decrease in body weight. Seven days after …