In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

The specific metabolic contribution of consuming different energy-yielding macronutrients
(namely, carbohydrates, protein and lipids) to obesity is a matter of active debate. In this …

Although discussion of the obesity epidemic had become a cocktail party cliché, its impact
on public health cannot be dismissed. In the past decade, cancer had joined the list of …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Background: The manipulation of pregnancy diets in animals can lead to changes in DNA
methylation with phenotypic consequences in the offspring. Human studies have …

Variation in body fat distribution contributes to the metabolic sequelae of obesity. The
genetic determinants of body fat distribution are poorly understood. The goal of this study …

Obesity is a multifactorial, complex, and public health problem worldwide. Interaction
between genes and environment as associated with diet may predispose an individual to …

Obesity is the result of the long‐term energy imbalance between the excess calories
consumed and the few calories expended. Reducing the intake of energy dense foods (fats …

The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and
has been implicated in regulation of virtually all cellular processes. MAPKs are divided into …