The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

The engineered cardiac patch (ECP) is a promising strategy to repair infarct myocardium
and restore the cardiac function. An ideal ECP should be able to mimic the primary attributes …

Rationale: Human pluripotent stem cell (hPSC)–derived cardiomyocytes exhibit the
properties of fetal cardiomyocytes, which limits their applications. Various methods have …

The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease
etiology, yet the majority of underlying signaling mechanisms are complex and not fully …

Background Injectable hydrogels have great promise in the treatment of myocardial
infarction (MI); however, the lack of electromechanical coupling of the hydrogel to the host …

Abstract Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes.
Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing …

The controversy between polypyrrole's (Ppy) biocompatibility and its aggregation on
nanofibers impedes application of conductive Ppy-incorporated nanofibers to create …