Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

Background Technologies for making and manipulating DNA have enabled advances in
biology ever since the discovery of the DNA double helix. But introducing site-specific …

The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered
regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a …

Targeted genome editing using engineered nucleases has rapidly gone from being a niche
technology to a mainstream method used by many biological researchers. This widespread …

The CRISPR-associated protein Cas9 is an RNA-guided endonuclease that cleaves double-
stranded DNA bearing sequences complementary to a 20-nucleotide segment in the guide …

The CRISPR-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA:
DNA base-pairing to target and cleave foreign DNA as part of an adaptive immune system in …

It is extremely rare for a single experiment to be so impactful and timely that it shapes and
forecasts the experiments of the next decade. Here, we review how two such experiments …

The discovery of clustered, regularly interspaced short palindromic repeats (CRISPR) and
their cooperation with CRISPR-associated (Cas) genes is one of the greatest advances of …

Targeted genome editing nucleases, such as zinc-finger nucleases (ZFNs) and transcription
activator-like effector nucleases (TALENs), are powerful tools for understanding gene …