Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Tumours evade immune control by creating hostile microenvironments that perturb T cell
metabolism and effector function,,–. However, it remains unclear how intra-tumoral T cells …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Nutrient-sensing mechanisms ensure that cellular activities are coordinated with nutrient
availability. Recent work has established links between metabolite pools and protein post …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadliest
cancer worldwide. The primary reasons for this are the lack of early detection methods and …

Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-
depleted tumor microenvironment, they can acquire nutrients via macropinocytosis, an …