[HTML][HTML] Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

TM Uddin, AJ Chakraborty, A Khusro… - Journal of infection and …, 2021 - Elsevier
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-
molecular-weight bioactive agents have also been used for a variety of other medicinal …

Mobile genetic elements associated with antimicrobial resistance

SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - Am Soc Microbiol
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Sequencing-based methods and resources to study antimicrobial resistance

M Boolchandani, AW D'Souza, G Dantas - Nature Reviews Genetics, 2019 - nature.com
Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

PlasFlow: predicting plasmid sequences in metagenomic data using genome signatures

PS Krawczyk, L Lipinski… - Nucleic acids research, 2018 - academic.oup.com
Plasmids are mobile genetics elements that play an important role in the environmental
adaptation of microorganisms. Although plasmids are usually analyzed in cultured …

plasmidSPAdes: assembling plasmids from whole genome sequencing data

D Antipov, N Hartwick, M Shen, M Raiko… - …, 2016 - academic.oup.com
Motivation: Plasmids are stably maintained extra-chromosomal genetic elements that
replicate independently from the host cell's chromosomes. Although plasmids harbor …

Plasmid evolution in carbapenemase‐producing Enterobacteriaceae: a review

K Kopotsa, J Osei Sekyere… - Annals of the New York …, 2019 - Wiley Online Library
Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐
priority pathogens owing to their high association with mortalities and morbidities …

On the (im) possibility of reconstructing plasmids from whole-genome short-read sequencing data

S Arredondo-Alonso, RJ Willems… - Microbial …, 2017 - microbiologyresearch.org
To benchmark algorithms for automated plasmid sequence reconstruction from short-read
sequencing data, we selected 42 publicly available complete bacterial genome sequences …

Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

AE Sheppard, N Stoesser, DJ Wilson… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a
major public health concern, as carbapenems are a therapy of last resort against this family …

[HTML][HTML] The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee

MJ Ellington, O Ekelund, FM Aarestrup… - Clinical microbiology …, 2017 - Elsevier
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility
from a single assay. The European Committee on Antimicrobial Susceptibility Testing …