Stem cell-based therapy has been one of the best documented approaches in regenerative
medicine, promising cures for a multitude of diseases and disorders. However, the ex vivo …

Chemokine signaling plays an important role in the postischemic inflammatory response.
Overlapping pathways involving reactive oxygen intermediates, Toll-like receptor (TLR) …

Mitochondrial damage and dysfunction occur during ischemia and modulate cardiac
function and cell survival significantly during reperfusion. We hypothesized that …

Human adult mesenchymal stem cells (MSCs) support the engineering of functional tissue
constructs by secreting angiogenic and cytoprotective factors, which act in a paracrine …

Rationale: Cardiac myocytes derived from pluripotent stem cells have demonstrated the
potential to mitigate damage of the infarcted myocardium and improve left ventricular …

Diabetic foot disease is a major health problem, which affects 15% of the 200 million
patients with diabetes worldwide. Diminished peripheral blood flow and decreased local …

Accumulating laboratory studies have implicated the mobilization of bone marrow (BM)-
derived stem cells in brain plasticity and stroke therapy. This mobilization of bone cells to the …

Cell therapy is a promising therapeutic option for treating patients with ischemic diseases.
The efficiency of cell therapy to augment recovery after ischemia depends on the sufficient …

Background and Purpose—Endothelial progenitor cells (EPCs) migrate from bone marrow
to systemic circulation in response to tissue ischemia where they differentiate into mature …

In this paper, we present a literature review of the role of CXC motif chemokine ligand 1
(CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular …