Glycoproteomics

I Bagdonaite, SA Malaker, DA Polasky… - Nature Reviews …, 2022 - nature.com
Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Global view of human protein glycosylation pathways and functions

KT Schjoldager, Y Narimatsu, HJ Joshi… - … reviews Molecular cell …, 2020 - nature.com
Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

G Liebisch, E Fahy, J Aoki, EA Dennis, T Durand… - Journal of lipid …, 2020 - ASBMB
A comprehensive and standardized system to report lipid structures analyzed by MS is
essential for the communication and storage of lipidomics data. Herein, an update on both …

Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

A single sulfatase is required to access colonic mucin by a gut bacterium

AS Luis, C Jin, GV Pereira, RWP Glowacki, SR Gugel… - Nature, 2021 - nature.com
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …

Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

RCSB Protein Data Bank: architectural advances towards integrated searching and efficient access to macromolecular structure data from the PDB archive

Y Rose, JM Duarte, R Lowe, J Segura, C Bi… - Journal of molecular …, 2021 - Elsevier
Abstract The US Research Collaboratory for Structural Bioinformatics Protein Data Bank
(RCSB PDB) serves many millions of unique users worldwide by delivering experimentally …

The emerging role of the mammalian glycocalyx in functional membrane organization and immune system regulation

L Möckl - Frontiers in cell and developmental biology, 2020 - frontiersin.org
All cells in the human body are covered by a dense layer of sugars and the proteins and
lipids to which they are attached, collectively termed the “glycocalyx.” For decades, the …

The Role of Pseudomonas aeruginosa Lipopolysaccharide in Bacterial Pathogenesis and Physiology

SM Huszczynski, JS Lam, CM Khursigara - Pathogens, 2019 - mdpi.com
The major constituent of the outer membrane of Gram-negative bacteria is
lipopolysaccharide (LPS), which is comprised of lipid A, core oligosaccharide, and O …

Glycoinformatics in the artificial intelligence era

D Bojar, F Lisacek - Chemical Reviews, 2022 - ACS Publications
Artificial intelligence (AI) methods have been and are now being increasingly integrated in
prediction software implemented in bioinformatics and its glycoscience branch known as …