Recent advances in single-cell sequencing technologies offer an opportunity to explore cell–
cell communication in tissues systematically and with reduced bias. A key challenge is …

No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

The growing availability of single-cell and spatially resolved transcriptomics has led to the
development of many approaches to infer cell–cell communication, each capturing only a …

Immune checkpoint inhibition treatment using aPD-1 monoclonal antibodies is a promising
cancer immunotherapy approach. However, its effect on tumor immunity is narrow, as most …

From single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics (ST), one can
extract high-dimensional gene expression patterns that can be described by intercellular …

Foxp3+ CD4+ regulatory T (Treg) cells found within tissues regulate local immunity,
inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are …

Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular
understanding of treatment response. We describe a therapeutic atlas for Crohn's disease …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Unravelling the origin and evolution of precancerous lesions is crucial for effectively
preventing malignant transformation, yet our current knowledge remains limited 1, 2, 3. Here …

Immunological priming—in the context of either prior infection or vaccination—elicits
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …