Introduction Vaccines based on multiple antigens often induce an immune response, which
is higher than that triggered by each single component, with antibodies acting cooperatively …

Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-
ordinated actions of a number of adhesins; many of which undergo antigenic and phase …

Factor H binding protein (fHbp) is a principal antigen in a multicomponent meningococcal
vaccine recently licensed in Europe for prevention of serogroup B diseases. The protein …

Background Meningococcal outer membrane vesicle (OMV) vaccines are efficacious in
humans but have serosubtype-specific serum bactericidal antibody responses directed at …

Introduction Species of the genus Neisseria are important global pathogens. Neisseria
gonorrhoeae (gonococcus) causes the sexually transmitted disease gonorrhea and …

The gene encoding the outer membrane adhesin/invasin protein OpcA was previously
described in the genomes of two pathogenic Neisseria species, N. meningitidis (Nm) and N …

Although effective against epidemic serogroup B Neisseria meningitidis strains, vaccines
based on outer membrane vesicles continue to present important limitations, and great …

Three recombinant proteins of Neisseria meningitidis, rPorB, rPorA, and rRmpM, were
purified and incorporated into liposomes prepared by dialysis-extrusion. The protein …

The endothelin (ET) system consists of two membrane receptor types A and B and three 21-
mer isopeptides endothelin-1, endothelin-2, and endothelin-3 as ligands. This system is …

ing capsule, surface sialic acids and pili. In addition, other relatively recently discovered OM
proteins are described briefly. Although not regarded as major proteins, these may play …