Collagen is the oldest and most abundant extracellular matrix protein that has found many
applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview …

Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

The cornea is a tough transparent tissue admitting and focusing light in the eye. More than
90% of the cornea is stroma, a highly organized, transparent connective tissue maintained …

DOI: 10.1002/adma. 201304428 development of the scaffold-free cell-sheet tissue
engineering (CSTE)[7] or tissue engineering by self-assembly (TESA),[8] a therapy that …

Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …

By most standard engineering practice principles, it is premature to credibly discuss the
“engineering” of a human cornea. A professional design engineer would assert that we still …

The corneal stroma contains a population of mesenchymal cells subjacent to the limbal
basement membrane with characteristics of adult stem cells. These 'niche cells' support …

Corneal blindness is a major cause of blindness in the world and corneal transplantation is
the only widely accepted treatment to restore sight in these eyes. However, it is becoming …

Therapeutic strategies based on the principles of tissue engineering by self-assembly put
forward the notion that functional regeneration can be achieved by utilising the inherent …

Purpose.: Corneal injury may ultimately lead to a scar by way of corneal fibrosis, which is
characterized by the presence of myofibroblasts and improper deposition of extracellular …