An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Recent scientific and technological advances have brought us closer to being able to apply
a true biopsychosocial approach to the study of resilience in humans. Decades of research …

Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …

A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Numerous studies have employed repeated social defeat stress (RSDS) to study the
neurobiological mechanisms of depression in rodents. An important limitation of RSDS …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Depression is caused by a change in neural activity resulting from an increase in glutamate
that drives excitatory neurons and may be responsible for the decline in the activity and …

There is an urgent need for more effective medications to treat major depressive disorder, as
fewer than half of depressed patients achieve full remission and many are not responsive …

The term “resilience” refers to the ability to adapt successfully to stress, trauma and
adversity, enabling individuals to avoid stress-induced mental disorders such as depression …