Long-term heavy cigarette smoking is a well-known high-risk factor for carcinogenesis in
various organs such as the head and neck, lungs, and urinary bladder. Furthermore …

To evaluate the oncologic prognostic value of fibroblast growth factor receptor (FGFR) and to
assess the safety and efficacy of its inhibitors in patients with urothelial bladder carcinoma. A …

Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)–chromatin
binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is …

Discrete bladder cancer molecular subtypes exhibit differential clinical aggressiveness and
therapeutic response, which may have significant implications for identifying novel …

Previously, we have identified the branched chain amino-acid transaminase 1 (BCAT1)
gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) …

Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that
lacks effective targeted therapies. The epithelial‐to‐mesenchymal transition (EMT) is a key …

Long non‑coding RNAs (lncRNAs) have important roles in diverse biological processes,
including transcriptional regulation, cell growth and tumorigenesis. The present study aimed …

Intratumoral heterogeneity in bladder cancer is a barrier to accurate molecular sub-
classification and treatment efficacy. However, individual cellular and mechanistic …

Purpose: Preclinical data indicate that DNA methyltransferase inhibition will circumvent
cisplatin resistance in various cancers. Patient and Methods: SPIRE comprised a dose …

Genomic and transcriptional studies have identified discrete molecular subtypes of bladder
cancer. These observations could be the starting point to identify new treatments. Several …