Synthetic progestogens (progestins) have been linked to increased breast cancer risk;
however, the role of endogenous progesterone in breast physiology and carcinogenesis is …

Animal models of cancer have been instrumental in advancing our understanding of the
biology of tumor initiation and progression, in studying gene function and in performing …

17β-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer.
As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors …

Neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD),
multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington disease, are …

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. The absence
of expression and/or amplification of estrogen and progesterone receptor as well as ERBB-2 …

This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the
mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human …

Background/Aims: The targeted therapy for triple-negative breast cancer (TNBC) is still
challenging due to poor understanding on its molecular etiology. The androgen receptor …

Abstract Lessons Learned Studies targeting the androgen receptor (AR) signaling pathway
in aromatase inhibitor (AI)‐resistant breast cancer are limited. Bicalutamide, one of the …

The aging-associated increase of cancer risk is linked with stromal fibroblast senescence
and concomitant cancer-associated fibroblast (CAF) activation. Surprisingly little is known …

The objective of this study was to determine the effects of Tribulus terrestris L.(TT) saponins
on exercise performance and the underlying mechanisms. A rat overtraining model was …