Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Drug delivery by supramolecular design

MJ Webber, R Langer - Chemical Society Reviews, 2017 - pubs.rsc.org
The rational design of drug delivery approaches leveraging supramolecular chemistry
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

CR Powell, KM Dillon, JB Matson - Biochemical pharmacology, 2018 - Elsevier
Hydrogen sulfide (H 2 S) is a ubiquitous small gaseous signaling molecule, playing an
important role in many physiological processes and joining nitric oxide and carbon …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos, EH Ohlstein - Pharmacological reviews, 2017 - Elsevier
Over the last decade, hydrogen sulfide (H 2 S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Peptide–drug conjugates as effective prodrug strategies for targeted delivery

Y Wang, AG Cheetham, G Angacian, H Su, L Xie… - Advanced drug delivery …, 2017 - Elsevier
Peptide–drug conjugates (PDCs) represent an important class of therapeutic agents that
combine one or more drug molecules with a short peptide through a biodegradable linker …

Self-assembling prodrugs

AG Cheetham, RW Chakroun, W Ma… - Chemical Society Reviews, 2017 - pubs.rsc.org
Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

A practical guide to working with H 2 S at the interface of chemistry and biology

MD Hartle, MD Pluth - Chemical society reviews, 2016 - pubs.rsc.org
Hydrogen sulfide (H2S) is the most recently accepted endogenously produced
gasotransmitter and is now implicated in a variety of physiological functions. In this tutorial …

Self-assembly, bioactivity, and nanomaterials applications of peptide conjugates with bulky aromatic terminal groups

IW Hamley - ACS Applied Bio Materials, 2023 - ACS Publications
The self-assembly and structural and functional properties of peptide conjugates containing
bulky terminal aromatic substituents are reviewed with a particular focus on bioactivity …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Hydrogen sulfide: an emerging precision strategy for gas therapy

H Ding, J Chang, F He, S Gai… - Advanced Healthcare …, 2022 - Wiley Online Library
Advances in nanotechnology have enabled the rapid development of stimuli‐responsive
therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2S) is a significant …