The basement membrane is an important extracellular matrix that is found in all epithelial
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …

In biological systems, form and function are inherently correlated. Despite this strong
interdependence, the biological effect of curvature has been largely overlooked or …

In this work a dual crosslinked network based on sodium alginate graft copolymer, bearing
poly (N-isopropylacrylamide-co-N-tert-butylacrylamide) P (NIPAM-co-NtBAM) side chains …

Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …

Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …

There is increasing evidence that surface curvature at a near-cell-scale influences cell
behaviour. Epithelial or endothelial cells lining small acinar or tubular body lumens, as those …

The fabrication of a large-scale microfluidic mold with 3D microstructures for manufacturing
of the conical microwell chip using a combined projection micro-stereolithography (PµSL) …

Cancer remains a severe public health burden worldwide. One of the challenges hampering
effective cancer therapy is that the existing cancer models hardly recapitulate the tumor …

Abstract 3D cell culture has been strongly advocated as a highly useful culture technique
instead of the traditional 2D cell culture. Specially, spheroids, as the primary mode of 3D cell …

Three-dimensional (3D) tissue culture has attracted a great deal of attention as a result of
the need to replace the conventional two-dimensional cell cultures with more meaningful …