Light-sheet microscopy is an imaging approach that offers unique advantages for a diverse
range of neuroscience applications. Unlike point-scanning techniques such as confocal and …

This paper reviews the rapid advances that have been made in one form of optical biological
imaging in the last decade, namely that of light sheet microscopy. Although the concept was …

The contrast and resolution of images obtained with optical microscopes can be improved
by deconvolution and computational fusion of multiple views of the same sample, but these …

Confocal microscopy remains a major workhorse in biomedical optical microscopy owing to
its reliability and flexibility in imaging various samples, but suffers from substantial point …

During development, coordinated cell behaviors orchestrate tissue and organ
morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful …

In recent years, light-sheet fluorescence microscopy (LSFM) has found a broad application
for imaging of diverse biological samples, ranging from sub-cellular structures to whole …

Detrimental effects of ionizing radiation (IR) are correlated to the varying efficiency of IR to
induce complex DNA damage. A double strand break (DSB) can be considered the simpler …

The field of fluorescence microscopy is rapidly growing and offers ever more imaging
capabilities for biologists. Over the past decade, many new technologies and techniques …

We improve multiphoton structured illumination microscopy using a nonlinear guide star to
determine optical aberrations and a deformable mirror to correct them. We demonstrate our …

Background Advances in tissue clearing and molecular labeling methods are enabling
unprecedented optical access to large intact biological systems. These developments fuel …