The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Obstacles and opportunities in a forward vision for cancer nanomedicine
I de Lázaro, DJ Mooney - Nature materials, 2021 - nature.com
Cancer nanomedicines were initially envisioned as magic bullets, travelling through the
circulation to target tumours while sparing healthy tissues the toxicity of classic …
circulation to target tumours while sparing healthy tissues the toxicity of classic …
Multifunctional biomolecule nanostructures for cancer therapy
J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
[HTML][HTML] The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy
Following its discovery more than 30 years ago, the enhanced permeability and retention
(EPR) effect has become the guiding principle for cancer nanomedicine development. Over …
(EPR) effect has become the guiding principle for cancer nanomedicine development. Over …
Biomedical polymers: synthesis, properties, and applications
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …
[HTML][HTML] Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect
V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …
macromolecules deliver their payload selectively to solid tumors. An important driver of …
Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy
Nanotechnology-based drug delivery platforms have been explored for cancer treatments
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …
Targeted delivery methods for anticancer drugs
VV Veselov, AE Nosyrev, L Jicsinszky, RN Alyautdin… - Cancers, 2022 - mdpi.com
Simple Summary The current main technological strategies for the delivery of anticancer
drugs are discussed herein. This comprehensive review may help researchers design …
drugs are discussed herein. This comprehensive review may help researchers design …