5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

A large number of 5-HT receptors (> 15) have been identified by molecular cloning
technology over the past 10 years. This review briefly summarizes available information …

Dexfenfluramine was approved in the United States for long-term use as an appetite
suppressant until it was reported to be associated with valvular heart disease. The valvular …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

The chemosensory capacity of the somatosensory system relies on the appropriate
expression of chemoreceptors, which detect chemical stimuli and transduce sensory …

The aim of the present study was to investigate changes in the plasma calcitonin gene-
related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) …

The present review gives an overview on the serotonin (5-hydroxytryptamine; 5-HT) system,
its receptors and their relationship to central nervous system physiology and disorders …

The purpose of this article is to summarize recent findings on the role of serotonin in pain
processing in the peripheral nervous system. Serotonin (5-hydroxtryptamine [5-HT]) is …