Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

The switch of tumor cells from an epithelial to a mesenchymal-like phenotype [designated as
epithelial-to-mesenchymal transition (EMT)] is known to induce tumor cell motility and …

It is clear from large clinical studies that selected chemokine receptors are often up-
regulated in a large number of common human cancers, including those of the breast, lung …

Inappropriate chemokine/receptor expression or regulation is linked to many diseases,
especially those characterized by an excessive cellular infiltrate, such as rheumatoid arthritis …

Improvement of ovarian cancer patient outcome requires well-characterized animal models
in which to evaluate novel therapeutics. Xenograft models are frequently used, but with little …

Although chemokines have been thought of primarily as leukocyte attractants, a growing
body of evidence indicates that they also contribute to a number of tumor‐related processes …

Degradation of elastin, the main amorphous component of elastic fibers, by elastases
belonging to the serine, metallo, or cysteine families leads to the generation of elastin …

Background Information: Previous studies have revealed that leptin may be involved in
epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate …

The drug efflux transporter ABCB5 identifies cancer stem–like cells (CSC) in diverse human
malignancies, where its expression is associated with clinical disease progression and …