Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or …

Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of
mesenchymal origin and a compelling clinical and biologic model for the rational …

Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that
occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic …

Gastrointestinal stromal sarcomas (GISTs) are the most common mesenchymal tumours
originating in the digestive tract. They have a characteristic morphology, are generally …

Gastrointestinal stromal tumors are rare malignancies involving the intestinal tract. They are
now easily recognized using standard immunohistochemistry. Management in the past was …

Gastrointestinal stromal tumors (GIST) are rare neoplasms arising from the interstitial cell of
Cajal in the gastrointestinal tract. Two thirds of GIST in adult patients have c-Kit mutation and …

Platelet‐derived growth factor (PDGF)‐mediated signalling has emerged as one of the most
extensively and deeply studied biological mechanism reported to be involved in regulation …

Background Gastrointestinal stromal tumours (GIST) are the most common mesenchymal
neoplasms of the gastrointestinal tract. Imatinib followed by sunitinib and regorafenib is the …

Background This investigator-initiated trial provided the justification for the phase III GRID
study resulting in worldwide regulatory approval of regorafenib as a third-line therapy for …

Cancer cells are disordered by nature and thus featured by higher internal redox level than
healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain …