Immunologic aspects of chronic obstructive pulmonary disease
This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …
environmental toxins can incite inflammatory and immunologic reactions that culminate in …
The vitamin D axis in the lung: a key role for vitamin D-binding protein
L Chishimba, DR Thickett, RA Stockley, AM Wood - Thorax, 2010 - thorax.bmj.com
There has been much recent interest in the role of the vitamin D axis in lung disease, which
includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also …
includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also …
Development and characterization of a high density SNP genotyping assay for cattle
The success of genome-wide association (GWA) studies for the detection of sequence
variation affecting complex traits in human has spurred interest in the use of large-scale high …
variation affecting complex traits in human has spurred interest in the use of large-scale high …
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
A genome-wide association study of pulmonary function measures in the Framingham Heart Study
The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
Genetics of ankylosing spondylitis
PC Robinson, MA Brown - Molecular immunology, 2014 - Elsevier
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and
sacroiliac joints. It causes significant disability and is associated with a number of other …
sacroiliac joints. It causes significant disability and is associated with a number of other …
Genome-wide association study of CSF levels of 59 Alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and …
Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are
strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including …
strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including …
PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo
K Klein, M Thomas, S Winter, AK Nussler… - Clinical …, 2012 - Wiley Online Library
Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely
heritable; however, predictive genetic factors have remained scarce. Using a candidate …
heritable; however, predictive genetic factors have remained scarce. Using a candidate …
A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle
The glutathionylation of intracellular protein thiols can protect against irreversible oxidation
and can act as a redox switch regulating metabolic pathways. In this study we discovered …
and can act as a redox switch regulating metabolic pathways. In this study we discovered …
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
LA Cupples, HT Arruda, EJ Benjamin… - BMC medical …, 2007 - Springer
Abstract Background The Framingham Heart Study (FHS), founded in 1948 to examine the
epidemiology of cardiovascular disease, is among the most comprehensively characterized …
epidemiology of cardiovascular disease, is among the most comprehensively characterized …