The healthcare industry generates enormous amounts of data, particularly in genomics,
which require effective handling, storage, and analysis. Cloud computing offers a promising …

The integration of DNA methylation and transcriptional state within single cells is of broad
interest. Several single-cell dual-and multi-omics approaches have been reported that …

DNA methylation represents a fundamental epigenetic mark that is associated with
transcriptional repression during development, maintenance of homeostasis, and disease …

Single-cell sequencing (SCS) is a next-generation sequencing method that is mainly used to
analyze differences in genetic and protein information between cells, to obtain genetic …

Bisulfite sequencing is considered as the gold standard approach for measuring DNA
methylation, which acts as a pivotal part in regulating a variety of biological processes …

肺癌是世界上死亡率最高的恶性肿瘤, 肿瘤内部存在着明显的异质性, 目前研究认为这种异质性
在肺癌研究中有重要的临床意义. 对于这种异质性的研究通常使用测序技术 …

肺癌是世界上死亡率最高的恶性肿瘤， 肿瘤内部存在着明显的异质性， 目前研究认为这种异质
性在肺癌研究中有重要的临床意义。 对于这种异质性的研究通常使用测序技术 …

Single-cell sequencing investigates the differences in the proteomic and genetic information
available about individual cells by using next-generation sequencing technologies. The …

A methyl group deposited on cytosines incorporated into the sequence of the DNA, so called
DNA methylation, decorates the genomes of a large number of species, from archaea to …

This dissertation work is motivated by the large influx of sequencing data: that is, both in
terms of the amount and the type of data, where current statistical and computational …