Background A new variant of SARS-CoV-2, B. 1.1. 7, emerged as the dominant cause of
COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the …

INTRODUCTION Genome sequencing at an unprecedented scale during the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is helping to track spread of …

The year 2020 was a turning point in history and in global health. The COVID-19 pandemic
has highlighted the potential for deadly epidemic-prone diseases to overwhelm our …

The unprecedented coverage offered by next-generation sequencing (NGS) technology has
facilitated the assessment of the population complexity of intra-host RNA viral populations at …

Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …

Abstract The development of High-Throughput Sequencing (HTS) technologies is having a
major impact on the genomic analysis of viral populations. Current HTS platforms can …

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …

Motivation High-throughput sequencing technologies are used increasingly not only in viral
genomics research but also in clinical surveillance and diagnostics. These technologies …

Several COVID-19 vaccines have shown good efficacy in clinical trials, but there remains
uncertainty about the efficacy of vaccines against different variants. Here, we investigate the …