How the splicing machinery defines exons or introns as the spliced unit has remained a
puzzle for 30 years. Here, we demonstrate that peripheral and central regions of the nucleus …

ABSTRACT A protein called cleavage-stimulating factor subunit 2 (CSTF2, additionally
called CSTF-64) binds RNA and is needed for the cleavage and polyadenylation of mRNA …

Post-transcriptional regulation by RNA binding proteins can determine gene expression
levels and drive changes in cancer cell proteomes. Identifying mechanisms of protein-RNA …

B cell lymphopoiesis requires dynamic modulation of the B cell transcriptome for timely
coordination of somatic mutagenesis and DNA repair in progenitor B (pro-B) cells. Here, we …

Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in
use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper …

Alternative splicing is pervasive in mammalian genomes and involved in embryo
development, whereas research on crosstalk of alternative splicing and embryo …

The preparation of biodegradable scaffolds loaded with cells and cytokine is a feature of
tissue‐engineered skin. IPSCs‐based tissue‐engineered skin treatment for wound repair is …

Alternative splicing is a crucial regulator in stem cell biology, intricately influencing the
functions of various biological macromolecules, particularly pre-mRNAs and the resultant …

T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many
tissues and in the vast majority of species, although it was first discovered as a component of …

Integrator cleaves nascent RNA, triggering RNA polymerase II transcription termination, but
how cleavage is regulated is poorly understood. Here we show hnRNPUL1 ensures efficient …