Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into
tissue architecture and cell development, especially in tumors. However, lacking …

The difficulty of converting scientific research findings into novel pharmacological treatments
for rare and life-threatening diseases is enormous. Biomarkers related to multiple biological …

Aging is the slowest process in a living organism. During this process, mortality rate
increases exponentially due to the accumulation of damage at the cellular level. Cellular …

Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential
for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how …

Due to a rapidly aging global population, osteoporosis and the associated risk of bone
fractures have become a wide-spread public health problem. However, osteoporosis is very …

Considering that cancer is resulting from the comutation of several essential genes of
individual patients, researchers have begun to focus on identifying personalized edge …

The dynamical network biomarker (DNB) theory detects the early warning signals of state
transitions utilizing fluctuations in and correlations between variables in complex systems …

The progression of complex diseases generally involves a pre-deterioration stage that
occurs during the transition from a healthy state to disease deterioration, at which a drastic …

Transcriptome profiles are sensitive to space stressors and serve as valuable indicators of
the biological effects during spaceflight. Herein, we transformed the expression profiles into …

Recent advances of single-cell RNA sequencing (scRNA-seq) technologies have led to
extensive study of cellular heterogeneity and cell-to-cell variation. However, the high …