The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …

Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …

DNA was selected over the course of evolution as the ideal molecule for coding and storing
the genetic blueprint of life. One primary driving force for selecting DNA as the repository for …

Conspectus Noncovalent DNA–protein interactions are at the heart of normal cell function. In
eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for …

Oxidatively damaged DNA results from the attack of sugar and base moieties by reactive
oxygen species (ROS), which are formed as byproducts of normal cell metabolism and …

Repair of oxidatively damaged bases in the genome via the base excision repair pathway is
initiated with excision of these lesions by DNA glycosylases with broad substrate range. The …

Prokaryotes and lower eukaryotes possess redundant activities that remove the plethora of
oxidative DNA base damages produced during normal oxidative metabolism and which …

The mild phenotype associated with targeted disruption of the mouse OGG1 and NTH1
genes has been attributed to the existence of back‐up activities and/or alternative pathways …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized
purines from damaged DNA. The Schiff base intermediate formed during this reaction …