Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Integrin adhesion receptors mediate the adhesion of blood cells, such as leukocytes, to
other cells, such as endothelial cells. Integrins also are critical for anchorage of …

Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …

The ubiquitously expressed phosphoinositide 3-kinase (PI3K) family of lipid kinases control
diverse cellular functions including cell survival, proliferation, metabolism and migration …

Phagocytic integrins are endowed with the ability to engulf and dispose of particles of
different natures. Evolutionarily conserved from worms to humans, they are involved in …

Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue
of their ability to independently promote actin polymerization. We demonstrate that …

The leading edge of migrating cells contains rapidly translocating activated integrins
associated with growing actin filaments that form 'sticky fingers' to sense extracellular matrix …

Protein kinase A (PKA) is a ubiquitous, promiscuous kinase whose activity is specified
through subcellular localization mediated by A-kinase anchoring proteins (AKAPs). PKA has …

Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How
intracellular signals promote talin binding to the integrin tail leading to integrin activation is …

Distinct integrin activation pathways for effector and regulatory T cell trafficking and function |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …