A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

Environmental epigenetics describes how environmental factors affect cellular epigenetics
and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Histones are characterized by numerous posttranslational modifications that influence gene
transcription,. However, because of the lack of global distribution data in higher eukaryotic …