Regulation of short-chain fatty acids in the immune system
X Liu, J Shao, YT Liao, LN Wang, Y Jia… - Frontiers in …, 2023 - frontiersin.org
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …
The impact of nutrition and environmental epigenetics on human health and disease
C Tiffon - International journal of molecular sciences, 2018 - mdpi.com
Environmental epigenetics describes how environmental factors affect cellular epigenetics
and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to …
and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to …
Identification of non-coding silencer elements and their regulation of gene expression
B Pang, JH van Weerd, FL Hamoen… - … Reviews Molecular Cell …, 2023 - nature.com
Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
S Ramazi, A Allahverdi, J Zahiri - Journal of biosciences, 2020 - Springer
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy
A Alqahtani, K Choucair, M Ashraf… - Future science …, 2019 - Taylor & Francis
Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …
results in aberrant gene expression in various diseases, including cancer. The …
Molecular mechanisms and potential functions of histone demethylases
SM Kooistra, K Helin - Nature reviews Molecular cell biology, 2012 - nature.com
Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …
nuclear processes. Histone methylation was originally believed to be an irreversible …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
Combinatorial patterns of histone acetylations and methylations in the human genome
Histones are characterized by numerous posttranslational modifications that influence gene
transcription,. However, because of the lack of global distribution data in higher eukaryotic …
transcription,. However, because of the lack of global distribution data in higher eukaryotic …