There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

GPR52 is a highly conserved, brain-enriched, G s/olf-coupled orphan G protein-coupled
receptor (GPCR) that controls various cyclic AMP (cAMP)-dependent physiological and …

Chemoproteomic profiling of cysteines has emerged as a powerful method for screening the
proteome-wide targets of cysteine-reactive fragments, drugs, and natural products. Herein …

Proteomic profiling using bioorthogonal chemical probes that selectively react with certain
amino acids is now a widely used method in life sciences to investigate enzymatic activities …

Achieving divergent synthesis from the same substrates quickly to generate different
products remains an attractive objective in synthetic chemistry and the medicinal industry …

Chromatographic purification of Elephantopus scaber led to 16 new germacrane-type
sesquiterpene lactones (1–16), named elephantopinolide AP, along with a known analogue …

We report here an unprecedented and highly enantioselective palladium‐catalyzed allylic
alkylation applied to 4‐substituted isoxazolidin‐5‐ones. Ultimately, the process provides a …

Abstract Alterbrassicicene D (1) and 3 (11)‐epoxyhypoestenone (2) were synthesised via a
two‐phase approach featuring concise construction of the 5‐8‐5 tricyclic intermediate and a …

The Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of enol carbonates derived from γ-
butyrolactones is reported, affording the corresponding enantioenriched α, α′-disubstituted …

Abiespiroside A (1), beshanzuenone C (2), and beshanzuenone D (3) belong to the Abies
sesquiterpenoid family. Beshanzuenones C (2) and D (3) are isolated from the critically …