Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic
alterations observed during the development of lower-grade glioma (LGG). LGG-associated …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …

The type I and III interferon (IFN) families consist of cytokines rapidly induced during viral
infection that confer antiviral protection on target cells and are critical components of innate …

The interface between an infectious agent and its host represents the ultimate battleground
for survival: The microbe must secure a niche for replication, whereas the host must limit the …

Interferons (IFNs) were discovered as cytokines induced during and protecting from viral
infection. They have been documented to play essential roles in numerous physiological …

We found upregulation of expression of the microRNA miR-155 in primary effector and
effector memory CD8+ T cells, but low miR-155 expression in naive and central memory …

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular
functions. The major signaling pathway activated by type I IFNs involves sequential …