Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …

Background Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive
oxygen species (ROS) that may subsequently cause severe white matter injury. The process …

Objective Because the role of white matter (WM) degenerating microglia (DM) in
remyelination failure is unclear, we sought to define the core features of this novel …

Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …

Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …

Patients with Alzheimer's disease (AD) often have cerebral white matter (WM)
hyperintensities on MRI and microinfarcts of presumed microvascular origin pathologically …

Vessel loss in the aging brain is commonly reported, yet important questions remain
concerning whether there are regional vulnerabilities and what mechanisms could account …