Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment
C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …
known to be associated with dementia caused by vascular factors, hypertension has more …
Hypertension, neurovascular dysfunction, and cognitive impairment
MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …
represents an important risk factor for vascular cognitive impairment and late-life dementia …
Advances in understanding the pathophysiology of lacunar stroke: a review
RW Regenhardt, AS Das, EH Lo, LR Caplan - JAMA neurology, 2018 - jamanetwork.com
Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …
[HTML][HTML] Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
J Zheng, J Lu, S Mei, H Wu, Z Sun, Y Fang, S Xu… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive
oxygen species (ROS) that may subsequently cause severe white matter injury. The process …
oxygen species (ROS) that may subsequently cause severe white matter injury. The process …
Ferroptosis of microglia in aging human white matter injury
PA Adeniyi, X Gong, E MacGregor… - Annals of …, 2023 - Wiley Online Library
Objective Because the role of white matter (WM) degenerating microglia (DM) in
remyelination failure is unclear, we sought to define the core features of this novel …
remyelination failure is unclear, we sought to define the core features of this novel …
[HTML][HTML] Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …
Pathophysiology of lacunar stroke: history's mysteries and modern interpretations
RW Regenhardt, AS Das, R Ohtomo, EH Lo… - Journal of Stroke and …, 2019 - Elsevier
Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …
Association of cerebral microvascular dysfunction and white matter injury in Alzheimer's disease
Patients with Alzheimer's disease (AD) often have cerebral white matter (WM)
hyperintensities on MRI and microinfarcts of presumed microvascular origin pathologically …
hyperintensities on MRI and microinfarcts of presumed microvascular origin pathologically …
Susceptibility to capillary plugging can predict brain region specific vessel loss with aging
B Schager, CE Brown - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
Vessel loss in the aging brain is commonly reported, yet important questions remain
concerning whether there are regional vulnerabilities and what mechanisms could account …
concerning whether there are regional vulnerabilities and what mechanisms could account …