A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Protein–protein interactions (PPIs) have emerged as important and challenging targets in
chemical biology and medicinal chemistry. The main difficulty encountered in the discovery …

Herein we review contemporary synthetic and protein design strategies to stabilize the α-
helical motif in short peptides and miniature proteins. Advances in organometallic catalyst …

Helix‐constrained polypeptides have attracted great interest for modulating protein–protein
interactions (PPI). It is not known which are the most effective helix‐inducing strategies for …

Recombinant proteins are important therapeutics due to potent, highly specific, and nontoxic
actions in vivo. However, they are expensive medicines to manufacture, chemically …

Abstract α-Helices are common secondary structural elements forming key parts of the large,
generally featureless interfacial regions of many therapeutically-relevant protein–protein …

The α-helix is the most abundant secondary structural element in proteins and is an
important structural domain for mediating protein–protein and protein–nucleic acid …