Towards clinical translation of FLASH radiotherapy

MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

FLASH radiotherapy: current knowledge and future insights using proton-beam therapy

JR Hughes, JL Parsons - International journal of molecular sciences, 2020 - mdpi.com
FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

[HTML][HTML] Technical challenges for FLASH proton therapy

S Jolly, H Owen, M Schippers, C Welsch - Physica Medica, 2020 - Elsevier
There is growing interest in the radiotherapy community in the application of FLASH
radiotherapy, wherein the dose is delivered to the entire treatment volume in less than a …

Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Dosimetry for FLASH radiotherapy: a review of tools and the role of radioluminescence and Cherenkov emission

MR Ashraf, M Rahman, R Zhang, BB Williams… - Frontiers in …, 2020 - frontiersin.org
While spatial dose conformity delivered to a target volume has been pushed to its practical
limits with advanced treatment planning and delivery, investigations in novel temporal dose …

[HTML][HTML] The European Joint Research Project UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

A Schüller, S Heinrich, C Fouillade, A Subiel… - Physica Medica, 2020 - Elsevier
UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse
dose rates is a recently started European Joint Research Project with the aim to develop and …

A framework for defining FLASH dose rate for pencil beam scanning

MM Folkerts, E Abel, S Busold, JR Perez… - Medical …, 2020 - Wiley Online Library
Purpose To develop a method of (a) calculating the dose rate of voxels within a proton field
delivered using pencil beam scanning (PBS), and (b) reporting a representative dose rate …

Comparison of FLASH proton entrance and the spread-out Bragg peak dose regions in the sparing of mouse intestinal crypts and in a pancreatic tumor model

MM Kim, II Verginadis, D Goia, A Haertter… - Cancers, 2021 - mdpi.com
Simple Summary FLASH radiotherapy is a treatment technique of interest that involves
radiation delivered at ultra-high dose rates> 100 times faster than traditional radiation …

The current status of preclinical proton FLASH radiation and future directions

ES Diffenderfer, BS Sørensen, A Mazal… - Medical …, 2022 - Wiley Online Library
We review the current status of proton FLASH experimental systems, including preclinical
physical and biological results. Technological limitations on preclinical investigation of …