The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

The scaffolding protein angiomotin (AMOT) is indispensable for vertebrate embryonic
angiogenesis. Here, we report that AMOT undergoes cleavage in the presence of …

Multiple myeloma (MM) cells suffer from baseline proteotoxicity as the result of an imbalance
between the load of misfolded proteins awaiting proteolysis and the capacity of the ubiquitin …

Ferroptosis is an iron-dependent cell death mechanism that may be important to prevent
tumor formation and useful as a target for new cancer therapies. Transcriptional networks …

Proteasome inhibitors, such as bortezomib, are first-line therapy against multiple myeloma
(MM). Unfortunately, patients frequently become refractory to this treatment. The transcription …

Background Alveolar echinococcosis (AE), which is caused by larval Echinococcus
multilocularis, is one of the world's most dangerous neglected diseases. Currently, no fully …

The human retroviral-like aspartic protease 1 (ASPRV1) is a retroviral-like protein that was
first identified in the skin due to its expression in the stratum granulosum layer of the …

Collective cell migration (CCM) is involved in multiple biological processes, including
embryonic morphogenesis, angiogenesis, and cancer invasion. However, the molecular …