Objective: Biomarkers are defined as anatomical, biochemical or physiological traits that are
specific to certain disorders or syndromes. The objective of this paper is to summarise the …

Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

▪ Abstract Breathing is a vital behavior that is particularly amenable to experimental
investigation. We review recent progress on three problems of broad interest.(i) Where and …

Context Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants
and maternal depression both alter neonatal health, and distinguishing the effects of each …

Intermittent hypoxia causes a form of serotonin-dependent synaptic plasticity in the spinal
cord known as phrenic long-term facilitation (pLTF). Here we show that increased synthesis …

Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

Molecular oxygen (O2) and carbon dioxide (CO2) are the primary gaseous substrate and
product of oxidative phosphorylation in respiring organisms, respectively. Variance in the …

Serotonergic neurons project widely throughout the CNS and modulate many different brain
functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) …

The rat retrotrapezoid nucleus (RTN) contains pH‐sensitive neurons that are putative central
chemoreceptors. Here, we examined whether these neurons respond to peripheral …

There is a growing appreciation that patients with seizures are also affected by a number of
comorbid conditions, including an increase in prevalence of depression (Kanner, 2009) …