Biomaterials in tendon and skeletal muscle tissue engineering: current trends and challenges

M Beldjilali-Labro, A Garcia Garcia, F Farhat, F Bedoui… - Materials, 2018 - mdpi.com
Tissue engineering is a promising approach to repair tendon and muscle when natural
healing fails. Biohybrid constructs obtained after cells' seeding and culture in dedicated …

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

V Citro, M Clerici, AR Boccaccini… - Journal of tissue …, 2023 - journals.sagepub.com
Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

In vitro innovation of tendon tissue engineering strategies

MR Citeroni, MC Ciardulli, V Russo… - International journal of …, 2020 - mdpi.com
Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Tendon and cytokine marker expression by human bone marrow mesenchymal stem cells in a hyaluronate/poly-lactic-co-glycolic acid (PLGA)/fibrin three-dimensional …

MC Ciardulli, L Marino, J Lovecchio, E Giordano… - Cells, 2020 - mdpi.com
We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-
transmission band of braided hyaluronate embedded in a cell localizing fibrin hydrogel and …

Growth factor delivery strategies for rotator cuff repair and regeneration

A Prabhath, VN Vernekar, E Sanchez… - International journal of …, 2018 - Elsevier
The high incidence of degenerative tears and prevalence of retears (20–95%) after surgical
repair makes rotator cuff injuries a significant health problem. This high retear rate is …

Mechanical activation drives tenogenic differentiation of human mesenchymal stem cells in aligned dense collagen hydrogels

H Park, SN Nazhat, DH Rosenzweig - Biomaterials, 2022 - Elsevier
Tendons are force transmitting mechanosensitive tissues predominantly comprised of highly
aligned collagen type I fibres. In this study, the recently introduced gel aspiration-ejection …

Current pharmacological approaches to the treatment of tendinopathy

R Aicale, RD Bisaccia, A Oliviero, F Oliva… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Tendinopathies are common in elite and recreational athletes: traditionally
considered overuse injuries, they involve excessive tensile loading and subsequent …

Tendon tissue engineering: Current progress towards an optimized tenogenic differentiation protocol for human stem cells

I Donderwinkel, RS Tuan, NR Cameron, JE Frith - Acta Biomaterialia, 2022 - Elsevier
Tendons are integral to our daily lives by allowing movement and locomotion but are
frequently injured, leading to patient discomfort and impaired mobility. Current clinical …

Advanced strategies for constructing interfacial tissues of bone and tendon/ligament

W Luo, Y Wang, Q Han, Z Wang, J Jiao… - Journal of Tissue …, 2022 - journals.sagepub.com
Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex
histological transition from soft to hard tissue, which significantly complicates its repair and …

A standalone bioreactor system to deliver compressive load under perfusion flow to hBMSC-seeded 3D chitosan-graphene templates

J Lovecchio, P Gargiulo, JL Vargas Luna, E Giordano… - Scientific reports, 2019 - nature.com
The availability of engineered biological tissues holds great potential for both clinical
applications and basic research in a life science laboratory. A prototype standalone …